Definitions
from Wiktionary, Creative Commons Attribution/Share-Alike License.
- noun biology The formation of
lymphatic vessels from pre-existing lymphatic vessels
Etymologies
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Examples
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However, a team of researchers, led by Sophia Tsai and Ming-Jer Tsai, at Baylor College of Medicine, Houston, has now identified a role for the gene regulatory protein COUP-TFII in lymphangiogenesis in mouse embryonic development and tumor lymphangiogenesis in adult mice.
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Although dysfunction in the lymphatic system contributes to human diseases such as the spread of cancer to other sites and lymphademas (localized fluid retention and tissue swelling), little is known about the molecules that regulate the formation of new lymphatic vessels, a process known as lymphangiogenesis.
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These data suggest that, in contrast to Spred1 and Spred2, which are important negative regulators of developmental lymphangiogenesis rather than developmental angiogenesis, as previously reported
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Therefore, drawing an analogy from the different functions of Sproutys and Spreds in Xenopus tropicalis, we propose that Sproutys inhibit PLC-γ / PKC-dependent VEGF-A signaling and angiogenesis, while Spreds inhibit Ras-dependent VEGF-C signaling and lymphangiogenesis.
PLoS ONE Alerts: New Articles Koji Taniguchi et al. 2009
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We showed that Sproutys are negative regulators for angiogenesis rather than lymphangiogenesis in vivo.
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Kobayashi N, Harada M, Takeoka M, Kawai Y, et al. (2008) Significance of tumor-associated stroma in promotion of intratumoral lymphangiogenesis: pivotal role of a hyaluronan-rich tumor microenvironment.
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In contrast to Spred1 and Spred2, which regulate developmental lymphangiogenesis, Sprouty2 and Sprouty4 are important negative regulators of developmental angiogenesis in vivo.
PLoS ONE Alerts: New Articles Koji Taniguchi et al. 2009
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"Not only did Judah Folkman single-handedly create the research discipline of angiogenesis, he also played a very fundamental role in the extension of the same principles to the field of lymphangiogenesis research," says Stanley G. Rockson, MD, Editor-in-Chief of the Journal and Chair of the Scientific Advisory Board of the Lymphatic Research Foundation.
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We also know that Spreds, in contrast, inhibit VEGF-C signaling, which is important in lymphangiogenesis, and that
PLoS ONE Alerts: New Articles Koji Taniguchi et al. 2009
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Since the degree of tumor lymphangiogenesis and vascularization may theoretically be related to the risk of lymph node metastasis, we sought to evaluate the relationship between lymph vessel invasion (LVI), lymphatic microvascular density (LVD), microvascular density (MVD) and VEGF-A expression, with SLN status and other known adverse clinical risk factors.
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