Definitions
from Wiktionary, Creative Commons Attribution/Share-Alike License.
- noun biology A form of
autophagy in which amembrane (thephagophore ) forms around the material to be digested before it fuses with thelysosome
Etymologies
Sorry, no etymologies found.
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Examples
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Npc1 −/− mice suggesting alterations in the degradative mechanism known as macroautophagy
PLoS ONE Alerts: New Articles Cristin D. Davidson et al. 2009
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Mitochondria with damaged mtDNA fuse with lysosomes for degradation via a form of autophagy known as macroautophagy
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It's called macroautophagy - autophagy means "self eating" - and within a week, breast cancer cells can reorganize component parts, degrade non-essentials and live in this state until antiestrogen therapy is stopped or the cells mutate and resume proliferation in the presence of tamoxifen.
Media Newswire 2008
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It's called macroautophagy - autophagy means "self eating" - and within a week, breast cancer cells can reorganize component parts, degrade non-essentials and live in this state until antiestrogen therapy is stopped or the cells mutate and resume proliferation in the presence of tamoxifen.
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It's called macroautophagy - autophagy means "self eating" - and within a week, breast cancer cells can reorganize component parts, degrade non-essentials and live in this state until antiestrogen therapy is stopped or the cells mutate and resume proliferation in the presence of tamoxifen.
Media Newswire 2008
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Our data demonstrate that [the drug] 17-AAG attenuated the formation of alpha-synuclein aggregates by stimulating macroautophagy. ...
Fight Aging! 2010
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Our data demonstrate that [the drug] 17-AAG attenuated the formation of alpha-synuclein aggregates by stimulating macroautophagy. ...
Fight Aging! 2010
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However, the precise mechanism behind macroautophagy malfunction in HD is poorly understood.
Naturejobs - All Jobs Marta Martinez-Vicente 2010
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Alterations in macroautophagy, the main process responsible for bulk autophagic degradation, have been proposed to contribute to pathogenesis in Huntington's disease (HD), a genetic neurodegenerative disorder caused by an expanded polyglutamine tract in the huntingtin protein.
Naturejobs - All Jobs Marta Martinez-Vicente 2010
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She'll now look for ways to block macroautophagy in an animal model, including using chloroquine, a drug used to treat malaria.
Media Newswire 2008
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