macroketone

Even when macroketone was given after tumors formed, most cancer spread was blocked.

PhysOrg.com - latest science and technology news stories PhysOrg Team 2010

Dr. Huang and his colleagues reported another key finding in the same Nature paper - on x-ray crystal structures of fascin and of the complex of fascin and macroketone.

PhysOrg.com - latest science and technology news stories PhysOrg Team 2010

Mice implanted with cancer cells and treated with the small molecule macroketone lived a full life without any cancer spread, compared with control animals, which all died of metastasis.

PhysOrg.com - latest science and technology news stories PhysOrg Team 2010

Dr. Huang and his research team have been working on macroketone since 2003.

PhysOrg.com - latest science and technology news stories PhysOrg Team 2010

"This suggests to us that an agent like macroketone could be used to both prevent cancer spread and to treat it as well," Dr. Huang says.

PhysOrg.com - latest science and technology news stories PhysOrg Team 2010

They demonstrated how macroketone blocks the activity of fascin.

PhysOrg.com - latest science and technology news stories 2010

They found that macroketone targets an actin cytoskeletal protein known as fascin that is critical to cell movement.

Warren Ellis Warren Ellis 2010

They found that macroketone targets an actin cytoskeletal protein known as fascin that is critical to cell movement.

Warren Ellis Warren Ellis 2010

Mice implanted with cancer cells and treated with the small molecule macroketone lived a full life without any cancer spread, compared with control animals, which all died of metastasis.

PhysOrg.com - latest science and technology news stories 2010

The images showed precisely how macroketone snugly nestles into a pocket of fascin affecting the way it regulates actin filament bundling.

PhysOrg.com - latest science and technology news stories PhysOrg Team 2010