Definitions
from Wiktionary, Creative Commons Attribution/Share-Alike License.
- noun cytology A form of
endocytosis in which a large fluid-filledvesicle , ormacropinosome , is pinched off from the cell membrane and brought into the interior of the cell
Etymologies
from Wiktionary, Creative Commons Attribution/Share-Alike License
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Examples
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* #4450 A new paradigm for AS1411 activity: Uptake by macropinocytosis and induction of macropinocytosis by a nucleolin-dependent mechanism (Reyes-Reyes et al.)
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* #4450 A new paradigm for AS1411 activity: Uptake by macropinocytosis and induction of macropinocytosis by a nucleolin-dependent mechanism (Reyes-Reyes et al.)
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Ogden CA, deCathelineau A, Hoffmann PR, Bratton D, Ghebrehiwet B, et al. (2001) C1q and mannose binding lectin engagement of cell surface calreticulin and CD91 initiates macropinocytosis and uptake of apoptotic cells.
PLoS ONE Alerts: New Articles Adi Tabib et al. 2009
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Johnson MT, Swanson JA (1996) A role for phosphoinositide 3-kinase in the completion of macropinocytosis and phagocytosis by macrophages.
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Wadia JS, Dowdy SF (2005) Cationic TAT peptide transduction domain enters cells by macropinocytosis.
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Magzoub M, Sandgren S, Lundberg P, Oglecka K, Lilja J, et al. (2006) N-terminal peptides from unprocessed prion proteins enter cells by macropinocytosis.
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The observations presented here using dominant-negative dynamin K44A and inhibitors of macropinocytosis indicate that, similar to the TAT protein transduction domain, endocytic uptake of PrP occurred by lipid-raft dependent macropinocytosis, and not caveloin or clathrin mediated endocytosis.
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However, specific inhibitors of macropinocytosis may potentially function more efficaciously to prevent initial cellular uptake of PrP
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We also found that inhibition of macropinocytosis was sufficient to prevent conversion of PrP
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Inhibition of macropinocytosis by three independent means prevented cellular uptake of recombinant PrP; however, it did not affect recombinant PrP cell surface association.
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