maytansine

The DM1 drug added to Herceptin was derived from an old chemotherapy drug called maytansine that was found to be too toxic for patients in clinical trials two decades ago.

BusinessWeek.com -- 2010

The new molecule consists of the trastuzumab monoclonal antibody, chemically fused to a cytotoxin: a potent microtubule inhibitor called maytansine that's derived from a sea sponge.

MedPageToday.com - medical news plus CME for physicians 2009

Chuchuhuasi contains a variety of naturally-occurring compounds, notably the two tumor-fighting alkaloids mayteine and maytansine.

FOXNews.com 2011

For the record, ornithologist Joseph Morlan says pyracantha berries contain hydrogen cyanide and maytansine

SFGate: Top News Stories home@sfchronicle.com (Joe Eaton 2010

Unlike naturally derived maytansine, DM1 can be connected to cancer-fighting antibodies, proteins produced by the body that seek out and attack only cancer cells.

The Seattle Times 2010

Jordan's report shows that a new synthetic version of maytansine called DM1, which is designed to destroy only cancer cells, has the same powerful anticancer effects as its natural cousin.

The Seattle Times 2010

The findings illuminate the work of ImmunoGen Inc., a Massachusetts-based drug company that designed the synthetic maytansine and tasked Jordan's lab with showing how it works.

The Seattle Times 2010

For the record, ornithologist Joseph Morlan says pyracantha berries contain hydrogen cyanide and maytansine

SFGate: Top News Stories home@sfchronicle.com (Joe Eaton 2010

University of California, Santa Barbara biologist Mary Ann Jordan said maytansine would affect healthy cells in addition to cancerous ones, causing severe side effects for patients.

The Seattle Times 2010

But while DM1 can disrupt cell replication like maytansine, it is distinguished by its ability to be sent directly to cancer cells.

The Seattle Times 2010