Definitions

from Wiktionary, Creative Commons Attribution/Share-Alike License.

  • noun A cytotoxic agent that inhibits the assembly of microtubules by binding to tubulin at the rhizoxin binding site.

Etymologies

from Wiktionary, Creative Commons Attribution/Share-Alike License

Maytenus +‎ -ine? from the plant from which it can be isolated.

Examples

  • The DM1 drug added to Herceptin was derived from an old chemotherapy drug called maytansine that was found to be too toxic for patients in clinical trials two decades ago.

    BusinessWeek.com --

  • The new molecule consists of the trastuzumab monoclonal antibody, chemically fused to a cytotoxin: a potent microtubule inhibitor called maytansine that's derived from a sea sponge.

    MedPageToday.com - medical news plus CME for physicians

  • Chuchuhuasi contains a variety of naturally-occurring compounds, notably the two tumor-fighting alkaloids mayteine and maytansine.

    FOXNews.com

  • For the record, ornithologist Joseph Morlan says pyracantha berries contain hydrogen cyanide and maytansine

    SFGate: Top News Stories

  • Unlike naturally derived maytansine, DM1 can be connected to cancer-fighting antibodies, proteins produced by the body that seek out and attack only cancer cells.

    The Seattle Times

  • Jordan's report shows that a new synthetic version of maytansine called DM1, which is designed to destroy only cancer cells, has the same powerful anticancer effects as its natural cousin.

    The Seattle Times

  • The findings illuminate the work of ImmunoGen Inc., a Massachusetts-based drug company that designed the synthetic maytansine and tasked Jordan's lab with showing how it works.

    The Seattle Times

  • For the record, ornithologist Joseph Morlan says pyracantha berries contain hydrogen cyanide and maytansine

    SFGate: Top News Stories

  • University of California, Santa Barbara biologist Mary Ann Jordan said maytansine would affect healthy cells in addition to cancerous ones, causing severe side effects for patients.

    The Seattle Times

  • But while DM1 can disrupt cell replication like maytansine, it is distinguished by its ability to be sent directly to cancer cells.

    The Seattle Times

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