from The American Heritage® Dictionary of the English Language, 4th Edition

  • n. A large bone marrow cell with a lobulate nucleus that gives rise to blood platelets.

from Wiktionary, Creative Commons Attribution/Share-Alike License

  • n. A large cell, found in bone marrow, responsible for the production of platelets.

from the GNU version of the Collaborative International Dictionary of English

  • n. A large bone marrow cell not usually found in the circulating blood; it is regarded as the precursors of blood platelets; it is up to 100 μm in diameter, with a polyploid nucleus. Also referred to as megacaryocyte, megalokaryocyte, and thromboblast.

from WordNet 3.0 Copyright 2006 by Princeton University. All rights reserved.

  • n. a large bone marrow cell; regarded as the source of blood platelets


From mega- +‎ karyocyte (Wiktionary)


  • Platelets are formed in the cytoplasm of a very large cell, the megakaryocyte.

    It's Always about the Blood

  • The cytoplasm of the megakaryocyte fragments at the edge of the cell.

    It's Always about the Blood

  • The condition also is characterized by proteolysis of platelet α-proteins such as platelet factor V and von Willebrand factor, further interfering with clot function, and with increased uPA messenger RNA levels, particularly during megakaryocyte differentiation. - medical news plus CME for physicians

  • "Our study indicates that the dysregulation of PLAU in Quebec platelet disorder extends beyond megakaryocyte lineage, to involve other cells of the myeloid lineage," the investigator said. - medical news plus CME for physicians

  • Lagrue-Lak-Hal AH, Debili N, Kingbury G, Lecut C, Le Couedic JP, et al. (2001) Expression and function of the collagen receptor GPVI during megakaryocyte maturation.

    PLoS ONE Alerts: New Articles

  • Boer AK, Los EL, Esselink MT, Vellenga E (2005) Stem cell factor synergistically enhances thrombopoietin-induced STAT5 signaling in megakaryocyte progenitors through JAK2 and Src kinase.

    PLoS ONE Alerts: New Articles

  • EPO - and SCF-induced STAT5 phosphorylation was largely restricted to the megakaryocyte-erythroid progenitor (MEP) compartment, while G-CSF as well IL-3 and GM-CSF were most efficient in inducing STAT5 phosphorylation in the myeloid progenitor compartments.

    PLoS ONE Alerts: New Articles

  • TPO influences megakaryocyte (MK) development by controlling proliferation, differentiation, survival and endoduplication

    PLoS ONE Alerts: New Articles

  • Hundred thousand 105 whole BM cells were assessed for megakaryocyte progenitor activity in a CFU-Mk assay, MegaCult-C (Stem cell Technologies, Vancouver, CA) per the manufacturer's instructions.

    PLoS ONE Alerts: New Articles

  • We hypothesize that SHIP might control megakaryocytopoiesis through effects on proliferation of megakaryocyte progenitors (MKP) and megakaryocytes (MK).

    PLoS ONE Alerts: New Articles


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