from Wiktionary, Creative Commons Attribution/Share-Alike License
- n. A gene expressed in melanocytes and involved in nevomelanocytic development; down-regulated in cases of melanoma
Australian researchers tested icilin, a potent cooling agent in peppermint, on a sensory pathway called transient receptor potential ion channel melastatin subtype 8 TRPM8, found in the colon and other parts of the body.
Du J, Rowan S, Hershey CL, Widlund HR, et al. (2004) Transcriptional regulation of the melanoma prognostic marker melastatin (TRPM1) by MITF in melanocytes and melanoma.
Ion channel transient receptor potential membrane melastatin 6 and 7 (TRPM6 and TRPM7) play a central role in magnesium homeostasis, which is critical for maintaining glucose and insulin metabolism.
It is an ion channel that is triggered by cold temperatures and small-molecule agonists and belongs to the melastatin subfamily - one of seven subfamilies of TRP proteins.