from Wiktionary, Creative Commons Attribution/Share-Alike License

  • n. A gene expressed in melanocytes and involved in nevomelanocytic development; down-regulated in cases of melanoma


from Wiktionary, Creative Commons Attribution/Share-Alike License

mela- +‎ statin, for melanocyte


  • Australian researchers tested icilin, a potent cooling agent in peppermint, on a sensory pathway called transient receptor potential ion channel melastatin subtype 8 TRPM8, found in the colon and other parts of the body.

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  • Du J, Rowan S, Hershey CL, Widlund HR, et al. (2004) Transcriptional regulation of the melanoma prognostic marker melastatin (TRPM1) by MITF in melanocytes and melanoma.

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  • Ion channel transient receptor potential membrane melastatin 6 and 7 (TRPM6 and TRPM7) play a central role in magnesium homeostasis, which is critical for maintaining glucose and insulin metabolism.

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  • It is an ion channel that is triggered by cold temperatures and small-molecule agonists and belongs to the melastatin subfamily - one of seven subfamilies of TRP proteins.



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