Definitions
from Wiktionary, Creative Commons Attribution/Share-Alike License.
- noun medicine A
sedative that is used to treatanxiety etc.
from WordNet 3.0 Copyright 2006 by Princeton University. All rights reserved.
- noun a sedative and tranquilizer (trade name Miltown and Equanil and Meprin) used to treat muscle tension and anxiety
Etymologies
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Examples
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The enzyme, coded for by the MEP1A gene, is a zinc-containing metalloprotease called meprin, and is abundant in the intestine.
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The Penn State team also discovered that meprin is able to activate an inflammatory serum factor produced by white blood cells, and this factor is elevated in both the mouse model of IBD and in humans with active IBD.
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With colleagues from the National Institutes of Health, she found a linkage between the meprin gene and vulnerability to diabetic nephropathy in Pima Indians in the southwestern United States.
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Mice lacking meprin had more severe intestinal damage after drinking a solution to induce inflammation, than did the wild-type mice that have meprin.
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These results indicate that meprin reduces the level of inflammation in the injured intestine.
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A nitric oxide level in the blood of mice lacking meprin was much higher than the level in wild-type mice.
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The researchers concluded that their findings strongly correlate the severity of inflammation associated with both Crohn's disease and ulcerative colitis with low meprin levels.
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She discovered meprin more than 25 years ago while at the Medical College of Virginia Commonwealth University.
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The association of the meprin gene with Crohn's disease remains to be characterized but disruption of the meprin gene affects the severity of both ulcerative colitis and Crohn's disease.
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They then compared the levels of meprin in affected and unaffected sections of colons from IBD patients and from healthy people.
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