methanethiosulfonate

Second, AMTS13 has most of the structural features of DDTMAHs but, since it possesses a slightly hydrophilic methanethiosulfonate group, it cannot be quite so effective in denaturing proteins.

PLoS ONE Alerts: New Articles Yuan-Ping Pang et al. 2009

This type of inhibition is fast (~30 min) and due to conjugation of the inhibitor to the active-site Cys of mosquito AP-AChE, according to our observed reactivation of the methanethiosulfonate-inhibited AChE by 2-mercaptoethanol.

PLoS ONE Alerts: New Articles Yuan-Ping Pang et al. 2009

Recently we reported that a methanethiosulfonate-containing molecule designed to target the active-site Cys residue irreversibly inhibited all AChE activity extracted from aphids while an identical exposure caused no effect on the human AChE

PLoS ONE Alerts: New Articles Yuan-Ping Pang et al. 2009

Although methanethiosulfonate is slightly hydrophilic, the overall structure of

PLoS ONE Alerts: New Articles Yuan-Ping Pang et al. 2009

Herein, we report that, under conditions that spare the human AChE, a methanethiosulfonate-containing molecule at 6 µM irreversibly inhibited 95% of the AChE activity extracted from

PLoS ONE Alerts: New Articles Yuan-Ping Pang et al. 2009

AMTS13 and Trp84 of AgAP-AChE, placing the methanethiosulfonate group at the rim of the gorge.

PLoS ONE Alerts: New Articles Yuan-Ping Pang et al. 2009

Moreover, the crystal structure shows that the methanethiosulfonate group is distant from Ser203.

PLoS ONE Alerts: New Articles Yuan-Ping Pang et al. 2009

AMTS13 structure: (1) a methanethiosulfonate group reactive toward free cysteine residues and (2) an alkyltrimethylammonium analogous to surfactant DDTMAHs.

PLoS ONE Alerts: New Articles Yuan-Ping Pang et al. 2009

[19], [20] and a methanethiosulfonate group on the other end to form an adduct preferentially with a free cysteine residue Figure 1 to replace the trimethylammonium and methanethiosulfonate groups of

PLoS ONE Alerts: New Articles Yuan-Ping Pang et al. 2009