Definitions
from Wiktionary, Creative Commons Attribution/Share-Alike License.
- noun organic chemistry A
tetrahydrofolate with amethyl substituent, a key natural form offolate . The chief form is 5-methyltetrahydrofolate.
Etymologies
from Wiktionary, Creative Commons Attribution/Share-Alike License
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Examples
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Biological plausibility for a relation between methyl groupdeficient diets and risk of pancreatic cancer includes a high, specific requirement for methyl group donors the pancreas contains high levels of folate derivates, including 5-methyltetrahydrofolate, which is the product of the reaction catalyzed by 5,10-methylenetetrahydrofolate reductase MTHFR.
Meat diet reduces risk of pancreatic cancer | The Blog of Michael R. Eades, M.D. 2007
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Take folate (especially in the active form of 5 methyltetrahydrofolate), B6 (in active form of P5P) and B12 (in the active form of methylcobalamin).
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Take folate (especially in the active form of 5 methyltetrahydrofolate), B6 (in active form of P5P) and B12 (in the active form of methylcobalamin).
Mark Hyman, MD: Glutathione: The Mother of All Antioxidants 2010
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In the laboratory, methylcobalamin can be made by a series of reactions involving the reduction of aquocobalamin to a compound, probably cobalamin hydride, which easily exchanges with methyl compounds such as diazomethane or methyl sulphate; in nature, reduction also seems necessary for methyl transfer; the experiments of D.D. Woods and his colleagues strongly suggest that methylcobalamin is the actual intermediate in one of the pathways by which methyl groups are transferred from methyltetrahydrofolate to homocysteine to form methionine 20.
Nobel Lecture The X-Ray Analysis Of Complicated Molecules 1964
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