from Wiktionary, Creative Commons Attribution/Share-Alike License

  • n. A protein and associated gene responsible for microcephaly


Sorry, no etymologies found.


  • In previous research, Dr. Lahn and associates discovered that a gene for brain size called microcephalin underwent a significant change 37,000 years ago.

    Neanderthals in the Gene Pool

  • The Chicago researchers began their study with two genes, known as microcephalin and ASPM, that came to light because they are disabled in a disease called microcephaly.

    Archive 2005-09-01

  • The research, led by Bruce T. Lahn of the University of Chicago, focused on two genes called microcephalin and ASPM.

    The Brain is Still Evolving | Impact Lab

  • If someone studied the ability of, say, the human microcephalin gene to generate resistance to penicillin in S. aureus, and found that it never did even when extensively mutagenized, only a fool would conclude that this means that S. aureus is incapable of developing resistance to penicillin.

    Behe's Test, Take 2

  • The second thing: while the much-debated origin of the recently derived and massively selected-for brain gene microcephalin can still be debated, you can no longer argue that this brain gene derived from Neanderthals.

    Archive 2008-12-01

  • Meanwhile, a team led by Bruce Lahn of the University of Chicago has been investigating a human gene called microcephalin.


  • A paper appearing online yesterday in PNAS free access, for once! reports strong evidence of introgression for a variant of the microcephalin gene, known to be involved in brain development and size.

    The Panda's Thumb: Andrea Bottaro Archives

  • To make a very long story short, it appears that a common human variant of the microcephalin gene originated on a chromosomal region that separated from the human lineage over 1 million years ago, only to come back “introgress” into H. sapiens about 37,000 years ago.

    The Panda's Thumb: Andrea Bottaro Archives

  • Dr. Bruce Lahn, a geneticist at the University of Chicago, published a report earlier this month suggesting that one of the two principal versions of the human gene for microcephalin, which helps determine brain size, came from an archaic population, presumably the Neanderthals.

    More Neanderthal News

  • Read Hawkes' Introgression and microcephalin FAQ for how this could occur.

    "So what did Neanderthal women do all day?"


Log in or sign up to get involved in the conversation. It's quick and easy.