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Examples
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We report the establishment of a library of micromolded elastomeric micropost arrays to modulate substrate rigidity independently of effects on adhesive and other material surface properties.
Naturejobs - All Jobs Jianping Fu 2010
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We demonstrated that micropost rigidity impacts cell morphology, focal adhesions, cytoskeletal contractility and stem cell differentiation.
Naturejobs - All Jobs Jianping Fu 2010
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"The library of micropost arrays spanned a more than 1,000-fold range of rigidity from 1.31 nN μm − 1 up to 1,556 nN μm − 1," said Chris Chen, lead author and the Skirkanich Professor of
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K measures micropost rigidity. (d-f) Scanning electron micrographs of hMSCs plated on PDMS micropost arrays of the indicated heights.
Naturejobs - All Jobs Jianping Fu 2010
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Figure 1: Micromolded elastomeric micropost arrays to engineer substrate rigidity.
Naturejobs - All Jobs Jianping Fu 2010
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"Furthermore, the micropost array library will be made available to researchers in other laboratories."
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Researchers created a library of micromolded, hexagonally spaced elastomeric micropost arrays, one to a few microns high, on which they cultivated cells.
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The micropost system allowed engineers to modulate the rigidity and flexibility of the substrate surface without changing the adhesive or other material surface properties that could affect cell growth.
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J.F. and M.T.Y. designed and fabricated micropost arrays.
Naturejobs - All Jobs Jianping Fu 2010
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(a) Brightfield micrographs of hMSCs stained for ALP and Lip after 14 d of culture in bipotential differentiation medium (MM) on micropost arrays of indicated rigidities.
Naturejobs - All Jobs Jianping Fu 2010
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