misincorporation

Neanderthal mtDNA sequences of the studied specimen, the pattern of nucleotide misincorporation among sequences consistent with post-mortem DNA damage and an accurate control of the MCPH1 alleles in all personnel that manipulated the sample, make it extremely unlikely that this result might reflect modern DNA contamination.

ScienceBlogs Channel : Life Science 2010

Neanderthal mtDNA sequences of the studied specimen, the pattern of nucleotide misincorporation among sequences consistent with post-mortem DNA damage and an accurate control of the MCPH1 alleles in all personnel that manipulated the sample, make it extremely unlikely that this result might reflect modern DNA contamination.

ScienceBlogs Channel : Life Science 2010

And that could lead to such things as new drugs that might correct the misincorporation of metals into cells that potentially can lead to diseases or disorders as well as new diagnostic methods for detecting diseases and in determining the toxic effects of heavy metals.

PhysOrg.com - latest science and technology news stories 2010

Secondly, chemical modification of the bases in ancient sequences, primarily the deamination of cytosine residues to uracil, can cause nucleotide misincorporation in newly synthesised DNA during PCR amplification or DNA sequencing

PLoS ONE Alerts: New Articles Ceiridwen J. Edwards et al. 2010

Uracil misincorporation into DNA and folic acid supplementation

American Journal of Clinical Nutrition current issue Hazra, A., Selhub, J., Chao, W.-H., Ueland, P. M., 2009

Folate deficiency decreases thymidylate synthesis from deoxyuridylate, which results in an imbalance of deoxyribonucleotide that may lead to excessive uracil misincorporation (UrMis) into

American Journal of Clinical Nutrition current issue Hazra, A., Selhub, J., Chao, W.-H., Ueland, P. M., 2009