mislocalization love

mislocalization

Definitions

from Wiktionary, Creative Commons Attribution/Share-Alike License

  • n. An incorrect or faulty localization

Etymologies

Sorry, no etymologies found.

Examples

  • Since localization of L-type calcium channels is critical for synchronous CICR, loss or mislocalization of these channels in the local microenvironment might lead to defective CICR and abnormal heart function.

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  • Therefore, depletion of BIN1 at T-tubule membrane after knockdown could result in mislocalization of Cav1. 2, causing inefficient excitation-contraction (EC) coupling and lethal cardiomyopathy.

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  • We found by confocal microscopy that mutation or deletion of either or both Arg 13 or Arg 14 caused mislocalization of PLN from the ER.

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  • Sterol-O-acyltransferase, three proteins identified in our bioinformatic screen also caused mislocalization of these known ER-resident proteins.

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  • Note that mutation of either Arg13 or Arg14, or both together, resulted in mislocalization of PLN out of the ER with significant expression at the plasma membrane.

    PLoS ONE Alerts: New Articles

  • Here we report that mutation or deletion of either arginine in the di-arginine motif results in mislocalization of PLN from the ER.

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  • The deletion of this sequence results in the mislocalization of SLN.

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  • Mutations deleting codons for either or both Arg13 or Arg14 resulted in the mislocalization of

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  • In order to gain direct evidence that a mutated di-arginine motif causes mislocalization to the plasma membrane, we co-transfected primary fibroblasts with either wildtype NF-PLN and a

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  • These data imply that COP I binds directly to the di-arginine motif in PLN, since mutation of this motif results in COP I not binding to PLN RΔ14 and its mislocalization to the plasma membrane.

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