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Examples
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A recent physicochemical study has revealed that the rat mitoribosome has a large molecular mass (3.57 MDa) compared with that of the Escherichia coli ribosome (2.49 MDa) (6), which is explained by the fact that the protein to RNA ratio is completely reversed between these two ribosomes (7).
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The mammalian mitoribosome contains no counterpart for the 5 S rRNA found in bacteria.
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Significant homology between mitoribosomal proteins and their bacterial counterparts indicates that the distribution of proteins within the mitoribosome and the prokaryotic ribosome is similar, as observed in a previous study on 39 S large subunit proteins 22.
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The mammalian mitoribosome contains no counterpart for the 5 S rRNA found in bacteria.
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The mammalian mitochondrial ribosome (mitoribosome)1 has a smaller sedimentation coefficient (55 S), compared with the bacterial ribosome (70 S), and consists of large 39 S and small 28 S subunits (5).
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The protein composition of the mitoribosome has been estimated to be about 75%, which indicates that large parts of bacterial rRNA domains have been replaced by protein components during mitochondrial evolution from a eubacteria-like endosymbiont in eukaryotic cell progenitors.
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The protein composition of the mitoribosome has been estimated to be about 75%, which indicates that large parts of bacterial rRNA domains have been replaced by protein components during mitochondrial evolution from a eubacteria-like endosymbiont in eukaryotic cell progenitors.
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The protein composition of the mitoribosome has been estimated to be about 75%, which indicates that large parts of bacterial rRNA domains have been replaced by protein components during mitochondrial evolution from a eubacteria-like endosymbiont in eukaryotic cell progenitors.
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A recent physicochemical study has revealed that the rat mitoribosome has a large molecular mass (3.57 MDa) compared with that of the Escherichia coli ribosome (2.49 MDa) (6), which is explained by the fact that the protein to RNA ratio is completely reversed between these two ribosomes (7).
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The mammalian mitochondrial ribosome (mitoribosome)1 has a smaller sedimentation coefficient (55 S), compared with the bacterial ribosome (70 S), and consists of large 39 S and small 28 S subunits (5).
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