Definitions

from Wiktionary, Creative Commons Attribution/Share-Alike License

  • n. A human gene, localized to filopodia and other membranous protrusions.

Etymologies

Initialism from membrane-organizing extension spike protein; see -in. (Wiktionary)

Examples

  • Always say, when you see bout a dozen buzzards moesin (flying) round a house en den dey break off en make a straight shoot for a graveyard, dere somebody out dat house gwine be bury dere soon.

    Slave Narratives: a Folk History of Slavery in the United States From Interviews with Former Slaves South Carolina Narratives, Part 1

  • Williams J, Klipfell E, Zarnescu D, Thomas G, et al. (2002) Crumbs interacts with moesin and beta (Heavy) - spectrin in the apical membrane skeleton of Drosophila.

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  • Yoshida T, Matsumura F, Ishizaki T, Narumiya S, et al. (2000) Rho-kinase/ROCK is involved in cytokinesis through the phosphorylation of myosin light chain and not ezrin/radixin/moesin proteins at the cleavage furrow.

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  • These actions were dependent on increased expression and phosphorylation of the actin-regulatory protein moesin and specific moesin siRNA severely impaired VEGF-C stimulated-cell migration.

    BioMed Central - Latest articles

  • Furthermore, in the surgical cervical specimen from the patients with FIGO stage at cervical intra-epithelial neoplasia and I-II cervical squamous cell carcinoma, the expression levels of moesin were found to be significantly correlated with tumor malignancy and metastasis.

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  • In this study, we investigated the effects of VEGF-C on actin cytoskeleton remodeling and on cervical cancer cell migration and invasion and how the actin-regulatory protein, moesin regulated these effects through RhoA/ROCK-2 signaling pathway.

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  • These results implied that VEGF-C promoted cervical cancer metastasis by upregulation and activation of moesin protein through RhoA/ROCK-2 pathway.

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  • The extracellular small GTPase RhoA/ROCK-2 cascade mediated the increased moesin expression and phosphorylation, which was discovered by the use of Y-27632, a specific inhibitor of Rho kinase and by transfected constitutively active, dominant-negative RhoA as well as ROCK-2 SiRNA.

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  • Tiede I, Fritz G, Becker C, Bartsch B, et al. (2006) Azathioprine suppresses ezrin-radixin-moesin-dependent t cell-apc conjugation through inhibition of vav guanosine exchange activity on rac proteins.

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