from The American Heritage® Dictionary of the English Language, 4th Edition

  • n. A highly toxic alkaloid, C9H20NO2, related to the cholines, derived from the red form of the mushroom Amanita muscaria and found in decaying animal tissue.

from Wiktionary, Creative Commons Attribution/Share-Alike License

  • n. An extremely poisonous alkaloid, obtained from fly agaric, that disrupts the action of acetylcholine neurotransmitter.

from The Century Dictionary and Cyclopedia

  • n. An extremely poisonous alkaloid (C5H13NO2) obtained from the fly-fungus, Agaricus muscarius.
  • n. A brownish-violet pulverulent dye, , prepared by the action of nitroso-dimethylaniline hydrochlorid on 2, 7-dihydroxynaphthalene.


New Latin muscāria, specific epithet (from feminine of Latin muscārius, of flies, from musca, fly) + -ine2.
(American Heritage® Dictionary of the English Language, Fourth Edition)
From the fungus Amanita muscaria, from Latin musca ("fly"). (Wiktionary)


  • Neurin is almost identical in its physiological effects with muscarine, which is described below.

    Studies of American Fungi. Mushrooms, Edible, Poisonous, etc.

  • For all such effects of acetylcholine, directly analogous to those which Loewi discovered in relation to the heart vagus, were covered by what I had termed the "muscarine" action of acetylcholine, and were all very readily suppressed by atropine.

    Sir Henry Dale - Nobel Lecture

  • It could be identified by its characteristic instability, and by the fact that its activity matched the same known concentration of acerylcholine in a series of different physiological tests, covering both "muscarine" and "nicotine" actions.

    Sir Henry Dale - Nobel Lecture

  • Through what I termed its "muscarine" action, it reproduced at the periphery all the effects of parasympathetic nerves, with a fidelity which, as I indicated, was comparable to that with which adrenaline had been shown, some ten years earlier, to reproduce those of true sympathetic nerves.

    Sir Henry Dale - Nobel Lecture

  • The meat of the story revolves around the following thesis statement: "It may well be the case that it was the cultivation of psychotropic substances rather than foodstuffs that prompted the initial development of agriculture, while fungal hallucinogens like psilocybin and muscarine were probably the catalyst responsible for the initial development of human self-consciousness."

    Archive 2008-03-01

  • A local shaman would eat the mushroom, using his body to filter out the poisonous muscarine; its mood-altering compounds were preserved in his urine, which was then ritually consumed by other Koryac and also some of the more favored reindeer.

    Soma and synchronicity

  • I vaguely recall that muscarine is only found in the younger shrooms; it looks like you'd want to avoid them, unless it's also responsible for most of the interesting effects. vince

    Natural Highs Frequently Asked Questions by Vince Cavasin

  • _Merck's_ sez that neither ibotenic acid and muscarine were "controlled substances" (what a * dumb* term) as of '76; was there maybe

    Natural Highs Frequently Asked Questions by Vince Cavasin

  • In looking for a substance with both these characteristics, I found that out of a series of the known vagomimetic substances, muscarine, piloearpin, choline, and acetylcholine, only the last-named possessed them7.

    Otto Loewi - Nobel Lecture

  • All these peripheral muscarine actions, these parasympathomimetic effects of acetylcholine, were very readily abolished by atropine.

    Sir Henry Dale - Nobel Lecture


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