from Wiktionary, Creative Commons Attribution/Share-Alike License.
- noun biochemistry Any of a family of
proteinsthat are RNA-binding factors
- noun genetics Any of the
genesassociated with these proteins
Sorry, no etymologies found.
One is called muscleblind-like, "which is sopped up by the RNA repeats, causing problems," said Cooper.
In this study scientists from the University of Rochester in New York found the blocking of a protein called "muscleblind" causes the characteristic hand stiffness.
"muscleblind," thought to be a key factor in myotonic dystrophy.
Most prominently, the transcribed CTG and CCTG repeats both bind muscleblind-like (MBNL) and CUGBP1/ETR-3-like factors (CELF) that are involved in alternative RNA splicing.
Urbinati CR, Teng-Umnuay P, Stenberg MG, Byrne BJ, et al. (2000) Recruitment of human muscleblind proteins to (CUG) (n) expansions associated with myotonic dystrophy.
Kanadia RN, Johnstone KA, Mankodi A, Lungu C, Thornton CA, et al. (2003) A muscleblind knockout model for myotonic dystrophy.
Other researchers are looking at molecules that can prevent muscleblind-like protein from binding RNA in the nucleus.
"In theory, if you could make that happen might you might actually make this disease go in reverse." molecule, succeeded in pulling apart the RNA and the muscleblind proteins.
To test whether CUGexp RNA creates a global splicing defect, we compared the skeletal muscle of two mouse models of DM1, one expressing a CTG exp transgene and another homozygous for a defective muscleblind 1 (