mutagenized

In an effort to increase the proportion of these proteins that fold into an ATP-binding conformation, we mutagenized the library and carried out further rounds of in vitro selection and amplification.

A Disclaimer for Behe? 2009

If someone studied the ability of, say, the human microcephalin gene to generate resistance to penicillin in S. aureus, and found that it never did even when extensively mutagenized, only a fool would conclude that this means that S. aureus is incapable of developing resistance to penicillin.

Behe's Test, Take 2 2008

Here we show, on the basis of comparative analysis of two extensively mutagenized ribozymes, that with a copying fidelity of 0.999 per digit per replication the phenotypic error threshold rises well above 7,000 nucleotides, which permits the selective maintenance of a functionally rich riboorganism with a genome of more than 100 different genes, the size of a tRNA.

Congratulations are in Order 2006

Here we show, on the basis of comparative analysis of two extensively mutagenized ribozymes, that with a copying fidelity of 0.999 per digit per replication the phenotypic error threshold rises well above 7,000 nucleotides, which permits the selective maintenance of a functionally rich riboorganism with a genome of more than 100 different genes, the size of a tRNA.

Congratulations are in Order 2006

We really mutagenized the DNA encoding this enzyme, so the effects are real.

Another Protozoan and Front-Loading 2006

The FR sequences can be mutagenized by substitution, insertion or deletion of at least one residue such that the FR sequence is distinct from the human and non-human antibody sequence employed.

FreshPatents.com: Notable Patent Applications - 07/22/2010 2010

Corresponding residues in PknJ were mutagenized to create double mutant T171A/T173A along with single mutants T168A, S172A and T179A and were compared with wild type protein.

PLoS ONE Alerts: New Articles Gunjan Arora et al. 2010

The researchers mutagenized their strain to create a partially resistant one, and cloned the gene that conferred resistance.

Ars Technica John Timmer 2010

Thus, mutagenized UbiA amino acids that resulted in loss of function aligned to UBIAD1 residues mutated in SCD.

PLoS ONE Alerts: New Articles Michael L. Nickerson et al. 2010

The CDR sequences can be mutagenized by substitution, insertion or deletion of at least one residue such that the CDR sequence is distinct from the human and non-human antibody sequence employed.

FreshPatents.com: Notable Patent Applications - 07/22/2010 2010