Definitions

from Wiktionary, Creative Commons Attribution/Share-Alike License

  • n. A transcription cofactor of the serum response factor

Etymologies

Sorry, no etymologies found.

Examples

  • Further analysis revealed that miR-143 and miR-145 are directly controlled by a protein called myocardin, which itself is sufficient to "reprogram" an adult non-muscle cell into a VSMC.

    EurekAlert! - Breaking News

  • Furthermore, the activation of these microRNAs by myocardin was a necessary event for myocardin to induce the VSMC fate.

    EurekAlert! - Breaking News

  • The discovery that miR-145 encourages the expression of myocardin could explain why myocardin may occur in higher levels in Alzheimer's disease, which is turning out to be a problem of "vascular plumbing."

    EurekAlert! - Breaking News

  • When levels of myocardin decrease, as they do for some reason in vascular diseases like atherosclerosis, VSMC no longer work normally and vessel thickening ensues.

    EurekAlert! - Breaking News

  • SRF anchors to certain snippets of DNA, while myocardin turns on the genes to which SRF sticks.

    EurekAlert! - Breaking News

  • Past studies in Rochester have shown that transition of VSMC from fast-proliferating stem cells to mature cells and back is largely controlled by two proteins, myocardin and serum response factor (SRF), as part of a regulatory network that influences many genes.

    EurekAlert! - Breaking News

  • Ph.D. found that when SRF and myocardin are active, amyloid beta accumulates in VSMC lining blood vessels.

    EurekAlert! - Breaking News

  • Most of the genes turned on by myocardin/SRF in VSMC are needed for normal function.

    EurekAlert! - Breaking News

  • "The finding that a microRNA controls levels of myocardin, the master regulator of VSM. identity and function, forms the starting point in efforts to design new classes of treatment for vascular diseases that represent leading causes of death," said Joseph M. M.ano, Ph. D., associate professor within the Aab Cardiovascular Research Institute at the University of Rochester M.dical Center, and a study author.

    EurekAlert! - Breaking News

  • These findings suggest that miR-143 and miR-145 - in partnership with myocardin - maintain the normal balance between mature VSMC and their precursors.

    EurekAlert! - Breaking News

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