from The Century Dictionary.
- noun In Gregarinida, the deeper layer of the ectoplasm containing a system of contractile fibrils: contrasted with
- noun A muscle-cell; the formative cellular element of the contractile tissue of most sponges. They are of various shapes, usually slenderly fusiform with long filamentous ends.
- noun Also
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- noun a single
from Wiktionary, Creative Commons Attribution/Share-Alike License
Corsini, A, et al. Relationship between mevalonate pathway and arterial myocyte proliferation: in vitro studies with inhibitors of HMGF-CoA reductase.
The delivery results in non-myocyte cells suggest that Cav1. 2 delivery to BIN1 is independent of other myocyte-specific organelles and proteins.
This process, which is known as calcium-induced calcium release (CICR) , is essential to each heartbeat and links electrical excitation of the myocyte and local calcium entry to its mechanical contraction.
Although a mutation in the transcription factor myocyte-specific enhancer factor 2 (dmef2) also blocks the initiation of fusion, this is likely due to defects in myoblast differentiation
To confirm that membrane delivery of Cav1. 2 to BIN1 can occur in non-myocyte cells, we evaluated surface expression patterns of exogenous Cav1. 2 in HeLa cells expressing exogenous BIN1.
Since Cav1. 2 delivery to BIN1 occurs in reductionist non-myocyte cell lines, we find that other myocyte-specific structures are not essential and there is an intrinsic relationship between microtubule-based Cav1. 2 delivery and its BIN1 scaffold.
Rudy-Reil D, Lough J (2004) Avian precardiac endoderm/mesoderm induces cardiac myocyte differentiation in murine embryonic stem cells.
Introduction of exogenous BIN1 forms membrane invaginations as previously reported in other non-myocyte cell types
In reductionist atrial myocyte and non-myocyte cell systems, BIN1 is sufficient to form membrane invaginations and distribute Cav1. 2 to these BIN1-containing membrane regions (visualized by total internal reflection microscopy, TIRFm).
Thereby, in the absence of other myocyte structures as well as the absence of endogenous Cav1. 2, ectopic expression of BIN1 is sufficient to concentrate surface Cav1. 2.