myofibre

Here, we report on the dynamics of postnatal myofibre growth in the mouse extensor digitorum longus (EDL) muscle, which is essentially composed of fast type II fibres in adult.

BioMed Central - Latest articles Robert White 2010

Postnatal fast muscle fibre type growth is divided into distinct phases in mouse EDL: myofibre hypertrophy is initially supported by a rapid increase in the number of myonuclei, but nuclear addition stops around P21.

BioMed Central - Latest articles Robert White 2010

Since the significant myofibre hypertrophy from P21 to adulthood occurs without the net addition of new myonuclei, a considerable expansion of the myonuclear domain results.

BioMed Central - Latest articles Robert White 2010

Here, we report on the dynamics of postnatal myofibre growth in the mouse extensor digitorum longus (EDL) muscle, which is essentially composed of fast type II fibres in adult.

BioMed Central - Latest articles Robert White 2010

Postnatal fast muscle fibre type growth is divided into distinct phases in mouse EDL: myofibre hypertrophy is initially supported by a rapid increase in the number of myonuclei, but nuclear addition stops around P21.

BioMed Central - Latest articles Robert White 2010

Where myofibre hypertrophy during growth requires the addition of new myonuclei, these are supplied by muscle satellite cells, the resident stem cells of skeletal muscle.

BioMed Central - Latest articles Robert White 2010

However, myofibre cross-sectional area increased by 7. 6-fold, and length by

BioMed Central - Latest articles Robert White 2010

Thus myofibre hypertrophy is initially accompanied by a significant addition of myonuclei.

BioMed Central - Latest articles Robert White 2010

We found that there was no net gain in myofibre number in the EDL between P7 and P56

BioMed Central - Latest articles Robert White 2010

We also used our two mouse models to determine the number of satellite cells per myofibre during postnatal growth.

BioMed Central - Latest articles Robert White 2010