from The American Heritage® Dictionary of the English Language, 4th Edition

  • n. Any of the threadlike fibrils that make up the contractile part of a striated muscle fiber. Also called sarcostyle.

from Wiktionary, Creative Commons Attribution/Share-Alike License

  • n. Cylindrical organelles, found within muscle cells, that are the contractile unit of muscles.

from The Century Dictionary and Cyclopedia

  • n. A muscle-fibril.

from WordNet 3.0 Copyright 2006 by Princeton University. All rights reserved.

  • n. one of many contractile filaments that make up a striated muscle fiber


from Wiktionary, Creative Commons Attribution/Share-Alike License

From myo- + fibril.


  • However, as the disease progresses, cardiomyocytes show deterioration in some mitochondrial as well as myofibril features, evidenced by swelling of mitochondria, misalignment of myofibril structure, and blurring as well as breakage of Z-lines.

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  • At 36 weeks of age, Tg mice (the group in transition from hypertrophy to HF) show significant degenerative changes in cardiomyocytes, including swelling of mitochondria, disruption of the nuclear membrane, and absence of myofibril structure.

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  • B, Ge K, Farmer G, et al. (2003) Targeted disruption of the murine Bin1/Amphiphysin II gene does not disable endocytosis but results in embryonic cardiomyopathy with aberrant myofibril formation.

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  • Occasional myocytes in both ventricles showed hypereosinophilia and loss of myofibril structure without associated inflammation (changes regarded as agonal rather than representing intrinsic myocyte pathology).

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  • When the shape changes a calcium ion is let through the S.R. into the myofibril causing the filaments to get excited causing them to contract.

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  • The appearance of Hand1 and Smyd1, transcription and chromatin remodeling factors; Acta1, Acta2, Myl3, and Myom1, myofibril proteins; and calcium-activated potassium-channel gene activity (KCNMB1), the channel protein, were powerfully attenuated in the

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