Definitions

from The American Heritage® Dictionary of the English Language, 5th Edition.

  • noun Any of the ultramicroscopic filaments, made up of actin and myosin, that are the structural units of a myofibril.

from Wiktionary, Creative Commons Attribution/Share-Alike License.

  • noun A filament within a myofibril, constructed from proteins.

Etymologies

from Wiktionary, Creative Commons Attribution/Share-Alike License

myo- +‎ filament

Examples

  • Third, while this data is focused on CM mutations in the thin filament regulatory system, nearly all CM mutants including the more prevalent thick filament mutants impact myofilament activation, either positively or negatively, to directly alter myofilament Ca

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  • Interestingly, a combination of a CM myofilament deactivating mutant, troponin C G159D, together with an activating mutant, cTnIR193H, produced a hybrid phenotype that blunted the strong activating phenotype of cTnIR193H alone.

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  • Dual expression of two CM mutants, that alone moderately increase myofilament activation, tropomyosin mutant A63V and cardiac troponin mutant R146G, were shown to additively slow myocyte relaxation beyond either mutant studied in isolation.

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  • These results also underscore that the primary outcome for double heterozygous patients may not necessarily cause a worsening of the disease phenotype particularly in cases where the genotype produces an activating and a deactivating mutant myofilament protein.

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  • Westfall MV, Rust EM, Metzger JM (1997) Slow skeletal troponin I gene transfer, expression, and myofilament incorporation enhances adult cardiac myocyte contractile function.

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  • Ahmed RP, Jagatheesan G, Petrashevskaya N, Boivin GP, et al. (2007) Dilated cardiomyopathy mutant tropomyosin mice develop cardiac dysfunction with significantly decreased fractional shortening and myofilament calcium sensitivity.

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  • An important outcome of the experimental results and model is that offspring inheriting two malignant CM alleles, that separately cause myofilament activation in one parent and deactivation in the other, could combine to produce a functional neutralization and benign presentation.

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  • Thus, co-transduction of intact adult cardiac myocytes with CM myofilament deactivator cTnCG159D together with myofilament activator cTnIR193H was examined.

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  • Given the central role of thin filament regulation on myocyte performance and the realization that both thin and thick filament CM mutant proteins directly alter myofilament activation

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  • We propose all CM sarcomeric can be incorporated into the model as they all fundamentally effect myofilament regulation

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