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- n. A protein (and associated gene) responsible for the development of skeletal muscle
Sorry, no etymologies found.
Histologically, the tumor was composed of two distinct components - an epithelioid component with granular cytoplasm that stained for synaptophysin, melan-A, calretinin, and vimentin compatible with adrenocortical differentiation, and a pleomorphic to spindled component that was positive for desmin and myogenin, compatible with rhabdomyosarcomatous differentiation.
We have previously demonstrated that TWEAK reduces the levels of MyoD and myogenin in differentiating C2C12 cultures
Interestingly, we have previously reported that TWEAK reduces the expression of MyoD and myogenin in C2C12 cultures
It has been recently demonstrated that knockdown of TCap in C2C12 myoblasts using siRNA reduces the expression of myogenic regulatory factors MyoD and myogenin suggesting that TCap might be required for the differentiation and maintenance of skeletal muscle mass
Since TWEAK significantly reduced the expression of TCap in cultured myotubes within 18h, these data suggest that TWEAK may also be affecting the levels of MyoD and myogenin through inhibiting the expression of TCap.
A highly conserved molecular switch binds MSY-3 to regulate myogenin repression in postnatal muscle.
 ultimately results in cell-cycle arrest through the upregulation of genes involved in cell-cycle withdrawal such as p21 and p53 and the downregulation of myogenic regulatory factors such as MyoD and myogenin