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Jena scientists from different disciplines founded a new network in order to utilize so-called nanocontainers for applications in the biomedical field ( "NanoConSens").
The insights gained from these investigations will form the basis for the subsequent development of prototypical nano-biosensors and design of membrane nanocontainers for drug delivery.
To develop microfluidic systems to allow the precise control of spatial distribution, orientation and manipulation of nanocontainers, zeolites L possessing 1D nanoscale channels, filled with molecules, for example fluorophores, to generate, for example, tunable optical systems.
Agashe HB, Garg M, Balakrishnan P, Kabra M, et al. (2007) Poly (propyleneimine) dendrimer based nanocontainers for targeting of efavirenz to human monocytes / macrophages in vitro.
"We aim at building up and optimizing various nanocontainers in such way that they - as intelligent transport vehicles - release active agents in the right dose at the right time at the right place in the human body", Prof.Dr. Ulrich S. S.hubert from the University in Jena describes the direction of the project.
Furthermore, modified nanocontainers can be employed as sensors for the investigation of living cells - for example to determine ionic concentration, temperature or pH value.
The new collaboration is, among other things, using combinations of novel concepts for building up star-shaped polymers, employing cationic polymers, varying the size of the nanocontainers and utilizing state-of-the-art methods of synthesis (like the so-called "click chemistry").