Definitions
from Wiktionary, Creative Commons Attribution/Share-Alike License
- n. Plural form of ncRNA.
Etymologies
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Examples
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Seven of the eight "unclassified ncRNA candidates" can be readily annotated as homologs of well-known ncRNAs.
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Analysis of the zebra finch genome sequence suggested that ncRNAs, which have been proposed to contribute to the evolution of greater complexity in humans and other animals, may be a driving force behind learned vocal communication.
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While many parts of the genome are engaged during vocal communication, one surprising finding was the extensive involvement of non-protein coding ribonucleic acids (ncRNAs).
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First, we analyzed the overlap between extragenic Pol_II sites and annotated ncRNAs datasets.
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Validation of 100 ncRNAs associated with predicted enhancers.
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The original set is made up of 1,673 domains that were remap to mm9 and filtered against the current Ensemble protein coding gene annotations, leading to a final set of 1,408 long ncRNAs.
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This led to a set of 3,122 macroRNAs that was further filtered against the current Ensemble protein coding gene annotations (mm_9) leading to 2,168 independent long ncRNAs.
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In some of these cases, it is implicit that the ncRNAs would act at the production site, possibly when still associated with elongating Pol_II.
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It is important to notice that the design of our study-which is based on the analysis of Pol_II occupancy in regions not overlapping annotated protein-coding genes-implies that gene boundaries, which contribute in a substantial manner to the repertoire of short and long ncRNAs in mammalian cells
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Mammalian genomes contain vast intergenic regions that are extensively transcribed and generate various types of short and long non-coding RNAs (ncRNAs).
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