Definitions
from Wiktionary, Creative Commons Attribution/Share-Alike License.
- adjective Relating to, or producing
necroinflammation
Etymologies
from Wiktionary, Creative Commons Attribution/Share-Alike License
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Examples
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ALT levels, and a 39 percent relative improvement in biopsy necroinflammatory scores, both measures of liver damage.
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ALT levels, and a 39 percent relative improvement in biopsy necroinflammatory scores, both measures of liver damage.
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C improves surrogate outcomes (alanine aminotransferase levels, histologic changes, and sustained virologic responses), these surrogates have never been validated. 2 In the HALT-C trial, maintenance therapy with peginterferon therapy improved inflammatory markers (alanine aminotransferase levels and necroinflammatory histologic findings) and reduced viral titers (producing more sustained virologic responses) without affecting clinical outcomes.
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Histologic improvement (greater than or equal to a two-point decrease in Knodell necroinflammatory score) and improvement in Knodell fibrosis score (greater than or equal to a one-point decrease) were evaluated for patients with biopsies at baseline, Week 48 and Week 148.
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Improvement in liver histology was defined as greater than or equal to a two-point decrease in Knodell necroinflammatory score and no worsening of Knodell fibrosis score.
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The co-primary long term histology endpoints were the proportion of patients with histologic improvement (defined as greater than or equal to a two-point decrease in Knodell necroinflammatory score and no worsening of Knodell fibrosis score) and the proportion of patients with improvement in Ishak fibrosis score (greater than or equal to a one-point decrease), both compared to baseline.
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