Definitions
from Wiktionary, Creative Commons Attribution/Share-Alike License
- n. New blood vessels
Etymologies
from Wiktionary, Creative Commons Attribution/Share-Alike License
neo- + vasculature
Examples
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Ocular diseases of neovasculature, AMD and diabetic retinopathy (DR), create aberrant retinal vessels by secreting pro-angiogenic factors to induce the angiogenic cascade.
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As inhibition of both TORC1 and TORC2 should result in greater control of PI3K/Akt/mTOR signaling, dual inhibitors such as P529 would be expected to exert increased activity in back of the eye diseases of neovasculature.
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These effects of TM601 on the neovasculature have also been validated in animal models of ophthalmic disease, including wet age-related macular degeneration (AMD).
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Bednarski M, Frausto R, Guccione S, Reisfeld RA, et al. (2002) Tumor regression by targeted gene delivery to the neovasculature.
Comments
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