neovasculature love


from Wiktionary, Creative Commons Attribution/Share-Alike License

  • n. New blood vessels


from Wiktionary, Creative Commons Attribution/Share-Alike License

neo- +‎ vasculature


  • Ocular diseases of neovasculature, AMD and diabetic retinopathy (DR), create aberrant retinal vessels by secreting pro-angiogenic factors to induce the angiogenic cascade.

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  • As inhibition of both TORC1 and TORC2 should result in greater control of PI3K/Akt/mTOR signaling, dual inhibitors such as P529 would be expected to exert increased activity in back of the eye diseases of neovasculature.

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  • These effects of TM601 on the neovasculature have also been validated in animal models of ophthalmic disease, including wet age-related macular degeneration (AMD).


  • Bednarski M, Frausto R, Guccione S, Reisfeld RA, et al. (2002) Tumor regression by targeted gene delivery to the neovasculature.

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