nepicastat

To confirm that the beneficial effects of disulfiram were because of dopamine beta-hydroxylase inhibition, the researchers turned to a drug called nepicastat, which was originally developed for the treatment of congestive heart failure in the 1990s.

GoodShit 2010

The company said it hopes the drug, called nepicastat, will help patients who have lost the ability to accurately assess danger, resulting in a constant sense of alertness.

Military Top Stories Center 2008

Roche has an option on the development and commercialization of SYN120 following an ongoing clinical imaging study using Positron Emission Tomography which is expected to complete in H1 2012. (nepicastat): An orally administered, potent and selective inhibitor of the enzymedopamine beta-hydroxylase (DBH).

Reuters: Press Release 2011

A Phase 2 study of nepicastat in post traumatic stress disorder is ongoing, funded by the US Department of Defense.

Reuters: Press Release 2011

"We reasoned that if disulfiram is really working through dopamine beta-hydroxylase, then nepicastat might be a better alternative."

GoodShit 2010

Researchers at Emory University School of Medicine in Atlanta say nepicastat was tried after the drug disulfiram -- which interferes with the body's ability to metabolize alcohol and results in a bad hangover -- was found to prevent cocaine addiction relapse.

Latest News - UPI.com 2010

To confirm the beneficial effects of dopamine beta-hydroxylase inhibition, researchers turned to the drug nepicastat -- developed in the 1990s to treat congestive heart failure.

Latest News - UPI.com 2010

Initial results about the effectiveness and tolerability of nepicastat are expected next spring, said Synosia spokesman Jan Gregor.

Military Top Stories Center 2008

a Phase I safety trial studying nepicastat for the treatment of cocaine addiction in human subjects.

GoodShit 2010