from Wiktionary, Creative Commons Attribution/Share-Alike License.
- noun Any of a group of
glycoproteinswhich act as transmembranereceptors in neurons
from Wiktionary, Creative Commons Attribution/Share-Alike License
Tran saw unusually pronounced "spines" sprouting willy-nilly in peculiar places and in greater numbers on the dendrites in the neurons of semaphorin-lacking and neuropilin-lacking mice compared to the normal wild-type animals.
The spines of both semaphorin-lacking and neuropilin-lacking mice were dramatically enlarged, compared to those of the smaller, spherical-looking spines in the wild-type mice.
Using two lines of mice - one missing semaphorin and another missing neuropilin, its receptor - postdoctoral fellow Tracy Tran used a classic staining method called the Golgi technique to look at the anatomy of nerve cells from mouse brains.
This included the upregulated neuropilin (NRP1) and plexin-A4 (PLXNA4), which together comprise the receptor for semaphorins