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Examples
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The company has conducted several Phase 2 clinical trials which have provided direct histologic evidence of nerve and blood vessel regrowth with SB-509 treatment and mechanistic proof of concept for the drug's neuroregenerative effects.
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The data included top-line, statistically significant data from the company's Phase 2 trial, SB-509-601, that established a mechanistic proof of concept for the neuroregenerative effects of SB-509 treatment as demonstrated by statistically significant increases in intraepidermal nerve fiber density (IENFD).
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The data generated to-date in our SB-509 program provides direct histological evidence of nerve regrowth and a mechanistic proof of concept for its neuroregenerative effects.
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There are no drugs that are neuroregenerative that are approved for treatment.
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The data demonstrated a direct neuroregenerative effect of SB-509 treatment that resulted in a statistically significant (p value = 0.02) increase in small unmyelinated nerve fibers in the skin, or intraepidermal nerve fiber density (IENFD), in subjects with DN.
unknown title 2009
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Together these data confirm the neuroregenerative activity of SB-509 in patients with DN and define a drug-responsive population for future trials.
unknown title 2009
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Recent study results demonstrated that arimoclomol exhibited both statistically significant neuroprotective and neuroregenerative effects in brain cells of animals induced with stroke, which further supports our data indicating its potential in treating a broad range of neurodegenerative diseases.
unknown title 2009
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In August 2009, CytRx reported that arimoclomol had exhibited both statistically significant neuroprotective and neuroregenerative effects in brain cells of animals induced with stroke, offering important insights into its mechanism of action.
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The data demonstrated a direct neuroregenerative effect of SB-509 treatment that resulted in a statistically significant (p value = 0.02) increase in small unmyelinated nerve fibers in the skin, or intraepidermal nerve fiber density (IENFD), in subjects with DN.
unknown title 2009
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Together these data confirm the neuroregenerative activity of SB-509 in patients with DN and define a drug-responsive population for future trials.
unknown title 2009
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