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- noun A
serine proteinase inhibitorthat is expressed in neuronsduring embryogenesisand in the adult nervous system
Sorry, no etymologies found.
Lawrence DA (2004) Tissue-type plasminogen activator and neuroserpin: a well-balanced act in the nervous system?
Inhibition of the proteasome with MG132 reveals that both mutant neuroserpin
We have used transient transfection of COS7 cells and mouse embryonic fibroblasts, PC12 cell lines that conditionally express wild type and mutant neuroserpin and fly models of FENIB to assess the cellular handling of wild type and mutant serpins.
At steady state, the fractions of intracellular polymerogenic G392E mutant neuroserpin in the monomeric and polymeric states are comparable.
. tPA expression as well as its inhibitors PAI-1 and neuroserpin are up-regulated in the acute stage of cerebral ischemia and hemorrhage
With specific inhibitors, i.e., plasminogen activator inhibitor (PAI) -1 (encoded by serpine 1 gene, secreted by neurons and active astrocytes) and neuroserpin (encoded by