Definitions

from Wiktionary, Creative Commons Attribution/Share-Alike License

  • n. A free-floating structure generated in vitro by neural stem cells

Etymologies

from Wiktionary, Creative Commons Attribution/Share-Alike License

neuro- +‎ sphere

Examples

  • These results may suggest that most cells in the hNPs remain in the PNS precursor state while some intrinsic PNS differentiation is taking place at the periphery of the neurosphere.

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  • The neurosphere transplants eventually grew into tumors and reignited the Notch pathway.

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  • In agreement with this hypothesis, we find that Nolz1 over-expression promotes cell cycle exit of NPCs in neurosphere cultures and negatively regulates proliferation in telencephalic organotypic cultures.

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  • Long-term human neurosphere cultures isolated from brain tissue (gestational 16-20 weeks) have been described previously

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  • This process theoretically selects for a NSC-enriched population; accordingly, these cells exhibit approximately a 2000-fold enhancement in neurosphere initiating capacity

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  • After 4 days in vitro, the fraction of wells positive for neurosphere formation was quantified.

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  • To obtain a direct evidence of the improved self-renewal capacity of T-IhNSC we performed a clonogenic, neurosphere assay.

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  • In addition to their proliferative capacity, an essential property of bona fide stem cells is their self-renewal potential, which can be demonstrated in neural stem cell cultures by observing a linear cell growth kinetic under the appropriate neurosphere assay conditions and in long-term cultures

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  • [18], which enriches the number of cells in the population with neurosphere-initiating capacity approximately 2000-fold.

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  • Figure 1C-G). showed that the expression of the neural crest marker HNK-1 is localized within the neurosphere (Figure

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