neurotropism

Occasionally, however, for some unknown reason, a mutant appears with marked reduction in both neurotropism as well as viscerotropism.

Max Theiler - Nobel Lecture 1964

Fox and his co-workers, the virus had regained some neurotropism so that it actually produced encephalitis in a small proportion of persons vaccinated.

Max Theiler - Nobel Lecture 1964

In their experiments a marked loss of neurotropism occurred in spite of the fact that in the developing chick embryo the virus shows a marked affinity for the brain and multiplies readily there.

Max Theiler - Nobel Lecture 1964

This attenuation consisted in a partial loss of neurotropism for mice and monkeys, as well as a marked loss of viscerotropism for monkeys.

Max Theiler - Nobel Lecture 1964

At intervals, monkeys were inoculated intracerebrally to determine the neurotropism of the cultivated virus.

Max Theiler - Nobel Lecture 1964

In the culture experiments with the JSS strain, maintained for over three hundred subcultures in the same media as were used for the French virus, the neurotropism tended to decrease in all three series.

Max Theiler - Nobel Lecture 1964

In like manner, the other two strains, which, it will be recalled, produced fatal encephalitis in monkeys at the beginning of these culture experiments, did not lose their neurotropism even though maintained for more than 200 subcultures in a medium containing minimal amounts of nervous tissue.

Max Theiler - Nobel Lecture 1964

While it was plain that the viscerotropic affinity could be readily reduced either by mouse brain passage or by prolonged tissue culture, what was particularly desired was a method of reducing the neurotropism.

Max Theiler - Nobel Lecture 1964

These results suggested that the amount of nervous tissue was the conditioning factor which produced the change, as loss of neurotropism occurred only in a medium containing minimal amounts of nervous tissue.

Max Theiler - Nobel Lecture 1964

Now the incubation period in mice is used as a measure of the degree of neurotropism for these animals.

Max Theiler - Nobel Lecture 1964