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AstraZeneca said an experimental antidepressant that mimics some of nicotine's mood-elevating effects failed in a large clinical trial, a setback for attempts to develop a successor to widely used antidepressants.

What's News— 2011

LONDON—U.K. drug maker AstraZeneca PLC said an experimental antidepressant that mimics some of nicotine's mood-elevating effects failed in a large clinical trial, a setback for the company's attempts to develop a possible successor to today's widely used antidepressants.

AstraZeneca Dealt Setback on Antidepressant Jeanne Whalen 2011

An unexpected drop in weight, blood pressure and respiration was recorded in nicotine subjects and can be partly explained by nicotine's mild anorexic effects, researchers said.

A New Weapon in the Fight Against Superbugs Ann Lukits 2012

AstraZeneca, based in the U.K., said it was scrapping further trials of an experimental antidepressant designed to mimic some of nicotine's mood-elevating effects.

AstraZeneca, Novartis Report Drug Setbacks Jeanne Whalen 2011

Targacept has said that TC-5214 lacks nicotine's addictive properties.

AstraZeneca Dealt Setback on Antidepressant Jeanne Whalen 2011

Targacept started out as a subsidiary of R.J. Reynolds, whose scientists spent decades studying nicotine's effects on the body.

AstraZeneca Dealt Setback on Antidepressant Jeanne Whalen 2011

Nicotine is a powerfully reinforcing drug and once the brain becomes dependent on nicotine's presence it is extremely difficult to stop using.

Barbara Ficarra: States Need Help, Smokers Have Hope 2009

Its argument is bolstered by voluminous evidence that the industry has long been aware of nicotine's addictive properties -- a charge the industry denies.

Firing Up The Politics Of Teen Smoking 2008

Named 'Chentix', it works by masquerading as 'nicotine' adequately enough to occupy the brain's 'nicotine's' receptors.

Why Smokers do not want to quit Smoking? 2008

Speak to Nicotine's Sad Grip Recent warnings that the smoking-cessation drug Chantix may cause erratic behavior and suicidal thoughts provide a new window into nicotine's dark and powerful grip on the brain.

Puff Power: Drug Warnings 2008