nigral

PINK1's interaction with HtrA2/OMI, for instance, appears to be independent of Parkin function in Loss of PINK1 and Parkin affects some cell populations, like substantia nigral neurons, more than others, even though PINK1 and Parkin appear to be more widely expressed.

PLoS Biology: New Articles Derek P. Narendra et al. 2010

One other explanation for this loss of nigral dopaminergic neurons could be the down regulation of TH expression in the dopaminergic cells.

PLoS ONE Alerts: New Articles Francisco Pan-Montojo et al. 2010

It is commonly established that the dynamics of growth factor function, neurotransmitter receptor and ion channel activity in nigral dopaminergic neurons are an important aspect of PD pathogenesis

PLoS ONE Alerts: New Articles Filip Simunovic et al. 2010

In this study, most of the impairments presented by C57BL/6 mice infused with a single intranasal administration of the proneurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) (1 mg/nostril) were similar to those observed during the early phase of PD, when a moderate loss of nigral dopamine neurons results in olfactory and memory deficits with no major motor impairments.

WN.com - Articles related to Food addiction 101: What is food addiction? 2010

We observed alpha-synuclein accumulation, phosphorylation, and inflammatory signs and loss of nigral TH

PLoS ONE Alerts: New Articles Francisco Pan-Montojo et al. 2010

Cantuti-Castelvetri I, Keller-McGandy C, Bouzou B, Asteris G, Clark TW, et al. (2007) Effects of gender on nigral gene expression and parkinson disease.

PLoS ONE Alerts: New Articles Filip Simunovic et al. 2010

Furthermore, underlying mechanism (s) by which microglial neuroinflammation kills the nigral dopaminergic neurons has not been fully delineated.

PLoS ONE Alerts: New Articles 2009

Thus, it can be questioned, what makes the nigral dopaminergic neurons substantially susceptible to mitochondrial dysfunction.

PLoS ONE Alerts: New Articles Dong-Young Choi et al. 2009

Interestingly, some of the remaining nigral dopaminergic neurons had intracytoplasmic accumulation of α-synuclein and ubiquitin.

PLoS ONE Alerts: New Articles Dong-Young Choi et al. 2009

Consistent with their report, we recently found that trichloroethylene causes selective loss of the nigral dopaminergic neurons in rats via complex I inhibition, and long term exposure to the chemical may be related to the development of parkinsonism in a group of factory workers

PLoS ONE Alerts: New Articles 2009