Definitions

from Wiktionary, Creative Commons Attribution/Share-Alike License.

  • adjective Of or pertaining to the substantia nigra.

Etymologies

from Wiktionary, Creative Commons Attribution/Share-Alike License

nigra +‎ -al

Examples

  • PINK1's interaction with HtrA2/OMI, for instance, appears to be independent of Parkin function in Loss of PINK1 and Parkin affects some cell populations, like substantia nigral neurons, more than others, even though PINK1 and Parkin appear to be more widely expressed.

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  • One other explanation for this loss of nigral dopaminergic neurons could be the down regulation of TH expression in the dopaminergic cells.

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  • It is commonly established that the dynamics of growth factor function, neurotransmitter receptor and ion channel activity in nigral dopaminergic neurons are an important aspect of PD pathogenesis

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  • In this study, most of the impairments presented by C57BL/6 mice infused with a single intranasal administration of the proneurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) (1 mg/nostril) were similar to those observed during the early phase of PD, when a moderate loss of nigral dopamine neurons results in olfactory and memory deficits with no major motor impairments.

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  • We observed alpha-synuclein accumulation, phosphorylation, and inflammatory signs and loss of nigral TH

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  • Cantuti-Castelvetri I, Keller-McGandy C, Bouzou B, Asteris G, Clark TW, et al. (2007) Effects of gender on nigral gene expression and parkinson disease.

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  • Furthermore, underlying mechanism (s) by which microglial neuroinflammation kills the nigral dopaminergic neurons has not been fully delineated.

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  • Thus, it can be questioned, what makes the nigral dopaminergic neurons substantially susceptible to mitochondrial dysfunction.

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  • Interestingly, some of the remaining nigral dopaminergic neurons had intracytoplasmic accumulation of α-synuclein and ubiquitin.

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  • Consistent with their report, we recently found that trichloroethylene causes selective loss of the nigral dopaminergic neurons in rats via complex I inhibition, and long term exposure to the chemical may be related to the development of parkinsonism in a group of factory workers

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