Definitions

from Wiktionary, Creative Commons Attribution/Share-Alike License

  • adj. That nitrates

Etymologies

Sorry, no etymologies found.

Examples

  • Increased superoxides can cause oxidative and nitrative damage to cell components.

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  • In agreement with cell and animal studies as well as clinical trials they also confirm the deleterious effects of Ang II which acts both in a chronic fashion by increasing the expression of NAD (P) Hoxidase and iNOS and in acute manner by activating them thereby leading to increased nitrative stress.

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  • These observations all point towards a major role of nitrative stress and protein nitration in the pathogenesis of insulin resistance and its complications.

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  • Since Ang II has been shown to induce oxidative and nitrative stress at physiological and low nanomolar concentrations, tyrosine nitration rather than S-nitrosation appears to be the most likely mechanism of Akt inhibition by this peptide in our model.

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  • Our data provide two novel targets, ERK1/2 and Akt, of a pathological nitrative stress resulting in the impairment of glucose uptake in skeletal muscle.

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  • Taken together, our data show that Ang II inhibits insulin-mediated GLUT4 translocation in this skeletal muscle model through at least two pathways: first through the transient activation of ERK1/2 which inhibit IRS-1/2 and second through a direct inhibitory nitration of Akt. These observations indicate that not only oxidative but also nitrative stress play a key role in the pathogenesis of insulin resistance.

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  • One can thus reasonably speculate that these latter conditions generated a nitrative rather than or parallel to a nitrosative stress.

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  • Paxinou E, Chen Q, Weisse M, Giasson BI, Norris EH, et al. (2001) Induction of alpha-synuclein aggregation by intracellular nitrative insult.

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  • However, the most interesting finding from the study came from preliminary experiments in which the researches observed that the extract reduced oxidative / nitrative stress in blood platelets from patients with breast cancer, showing the Aronia berry to contain an important antioxidant for that group of people.

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  • and ARBs have been reported to selectively inhibit iNOS and NAD (P) Hoxidase expression and activity as well as nitrative stress in both type 1 and

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