Definitions
from Wiktionary, Creative Commons Attribution/Share-Alike License
- adj. That nitrates
Etymologies
Sorry, no etymologies found.
Examples
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Increased superoxides can cause oxidative and nitrative damage to cell components.
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In agreement with cell and animal studies as well as clinical trials they also confirm the deleterious effects of Ang II which acts both in a chronic fashion by increasing the expression of NAD (P) Hoxidase and iNOS and in acute manner by activating them thereby leading to increased nitrative stress.
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These observations all point towards a major role of nitrative stress and protein nitration in the pathogenesis of insulin resistance and its complications.
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Since Ang II has been shown to induce oxidative and nitrative stress at physiological and low nanomolar concentrations, tyrosine nitration rather than S-nitrosation appears to be the most likely mechanism of Akt inhibition by this peptide in our model.
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Our data provide two novel targets, ERK1/2 and Akt, of a pathological nitrative stress resulting in the impairment of glucose uptake in skeletal muscle.
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Taken together, our data show that Ang II inhibits insulin-mediated GLUT4 translocation in this skeletal muscle model through at least two pathways: first through the transient activation of ERK1/2 which inhibit IRS-1/2 and second through a direct inhibitory nitration of Akt. These observations indicate that not only oxidative but also nitrative stress play a key role in the pathogenesis of insulin resistance.
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One can thus reasonably speculate that these latter conditions generated a nitrative rather than or parallel to a nitrosative stress.
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Paxinou E, Chen Q, Weisse M, Giasson BI, Norris EH, et al. (2001) Induction of alpha-synuclein aggregation by intracellular nitrative insult.
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However, the most interesting finding from the study came from preliminary experiments in which the researches observed that the extract reduced oxidative / nitrative stress in blood platelets from patients with breast cancer, showing the Aronia berry to contain an important antioxidant for that group of people.
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and ARBs have been reported to selectively inhibit iNOS and NAD (P) Hoxidase expression and activity as well as nitrative stress in both type 1 and
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