nitrative

Paxinou E, Chen Q, Weisse M, Giasson BI, Norris EH, et al. (2001) Induction of alpha-synuclein aggregation by intracellular nitrative insult.

PLoS ONE Alerts: New Articles Diane Latawiec et al. 2010

Since Ang II has been shown to induce oxidative and nitrative stress at physiological and low nanomolar concentrations, tyrosine nitration rather than S-nitrosation appears to be the most likely mechanism of Akt inhibition by this peptide in our model.

PLoS ONE Alerts: New Articles Alfredo Csibi et al. 2010

Increased superoxides can cause oxidative and nitrative damage to cell components.

Naturejobs - All Jobs Nesreen S Ismail 2010

One can thus reasonably speculate that these latter conditions generated a nitrative rather than or parallel to a nitrosative stress.

PLoS ONE Alerts: New Articles Alfredo Csibi et al. 2010

Our data provide two novel targets, ERK1/2 and Akt, of a pathological nitrative stress resulting in the impairment of glucose uptake in skeletal muscle.

PLoS ONE Alerts: New Articles Alfredo Csibi et al. 2010

These observations all point towards a major role of nitrative stress and protein nitration in the pathogenesis of insulin resistance and its complications.

PLoS ONE Alerts: New Articles Alfredo Csibi et al. 2010

Increased superoxides can cause oxidative and nitrative damage to cell components.

Naturejobs - All Jobs Nesreen S Ismail 2010

In agreement with cell and animal studies as well as clinical trials they also confirm the deleterious effects of Ang II which acts both in a chronic fashion by increasing the expression of NAD (P) Hoxidase and iNOS and in acute manner by activating them thereby leading to increased nitrative stress.

PLoS ONE Alerts: New Articles Alfredo Csibi et al. 2010

Taken together, our data show that Ang II inhibits insulin-mediated GLUT4 translocation in this skeletal muscle model through at least two pathways: first through the transient activation of ERK1/2 which inhibit IRS-1/2 and second through a direct inhibitory nitration of Akt. These observations indicate that not only oxidative but also nitrative stress play a key role in the pathogenesis of insulin resistance.

PLoS ONE Alerts: New Articles Alfredo Csibi et al. 2010

However, the most interesting finding from the study came from preliminary experiments in which the researches observed that the extract reduced oxidative / nitrative stress in blood platelets from patients with breast cancer, showing the Aronia berry to contain an important antioxidant for that group of people.

Signs of the Times 2009