from Wiktionary, Creative Commons Attribution/Share-Alike License
- n. The N-oxide of an imine
Sorry, no etymologies found.
It appears that the nitrone spin traps are efficacious in preventing precancers and cancers in the liver of animal models.
When the scientists administered nitrone spin traps to stroke patients, they noticed a significant decrease in the incidence of such problems as paralysis and loss of speech.
As for cinnamic aldehyde, the curcuminoids, and the nitroalkenes, I believe the anticancer activity and other therapeutic benefits of a nitrone spin trap results from the fact that it is a mild electrophile and a Michael acceptor pharmacophore.
In looking at the molecular structure of the PBN nitrone spin traps, I recognized a familiar structure, one that is seen in the Michael acceptor pharmacophores in cinnamic aldehyde, the curcuminoids found in turmeric, and the nitroalkenes described earlier in this chapter.
One of the persistent themes in Dr. Floyd’s journal articles is the unknown mechanism of action of the nitrone spin traps.
When I presented this nitrone spin trap mechanism of action hypothesis to Dr. Floyd, he wasn’t quite convinced, but I believe that he and his colleagues are seriously considering this explanation.
(first oxidation to the N - hydroxy amine and then to the corresponding nitrone )  S tamoxifen + NADPH + O2