nitrosylation

Treatments that imitate this process, called nitrosylation, were tested on cell cultures, human specimens and mice genetically altered to mimic human disease.

For a Mother's Touch, Skip the Text Messages Ann Lukits 2011

Several major forms of oxidative modifications can occur on amino acid residue side chains, including carbonylation, nitrosylation, and oxidation of methionine to methionine sulfoxide

PLoS ONE Alerts: New Articles Franco Folli et al. 2010

S-nitrosylation or nitrosation is the modification of sulfhydryl (- SH) to S-nitroso (- SNO) groups and appears to occur at a molar NO/O

PLoS ONE Alerts: New Articles Alfredo Csibi et al. 2010

Other post-translational modifications of HIF-1α, such as acetylation, phosphorylation and nitrosylation, were also reported, despite contradictory results with regard to their effect on HIF-1α protein stability and transcriptional activity

PLoS ONE Alerts: New Articles Daniela Trisciuoglio et al. 2010

Yasukawa T, Tokunaga E, Ota H, Sugita H, Martyn JA, et al. (2005) S-nitrosylation-dependent inactivation of Akt/protein kinase B in insulin resistance.

PLoS ONE Alerts: New Articles Alfredo Csibi et al. 2010

Furthermore, defect in the mitochondrial respiratory chain, and extensive S-nitrosylation / nitration of mitochondrial complex I were detected prior to the dopaminergic neuronal loss.

PLoS ONE Alerts: New Articles Dong-Young Choi et al. 2009

L-NIL treatment appears to prevent the LPS-induced increase of S-nitrosylation (C, D).

PLoS ONE Alerts: New Articles Dong-Young Choi et al. 2009

Here, we showed that neuroinflammation is able to mediate mitochondrial impairment by S-nitrosylation / nitration of mitochondrial proteins.

PLoS ONE Alerts: New Articles Dong-Young Choi et al. 2009

Thomas B, Li X, Pletnikova O, Troncoso JC, et al. (2004) S-nitrosylation of parkin regulates ubiquitination and compromises parkin's protective function.

PLoS ONE Alerts: New Articles 2009

These results implicate neuroinflammation-induced S-nitrosylation / nitration of mitochondrial complex I in mitochondrial malfunction and subsequent degeneration of the nigral dopamine neurons.

PLoS ONE Alerts: New Articles Dong-Young Choi et al. 2009