Definitions

from Wiktionary, Creative Commons Attribution/Share-Alike License

  • n. The reaction of nitric oxide with a biological compound, especially with a sulfur containing part of a protein as a posttranslational modification
  • n. Any reaction with a nitrosyl compound

Etymologies

Sorry, no etymologies found.

Examples

  • Treatments that imitate this process, called nitrosylation, were tested on cell cultures, human specimens and mice genetically altered to mimic human disease.

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  • Several major forms of oxidative modifications can occur on amino acid residue side chains, including carbonylation, nitrosylation, and oxidation of methionine to methionine sulfoxide

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  • Yasukawa T, Tokunaga E, Ota H, Sugita H, Martyn JA, et al. (2005) S-nitrosylation-dependent inactivation of Akt/protein kinase B in insulin resistance.

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  • S-nitrosylation or nitrosation is the modification of sulfhydryl (- SH) to S-nitroso (- SNO) groups and appears to occur at a molar NO/O

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  • Other post-translational modifications of HIF-1α, such as acetylation, phosphorylation and nitrosylation, were also reported, despite contradictory results with regard to their effect on HIF-1α protein stability and transcriptional activity

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  • Thomas B, Li X, Pletnikova O, Troncoso JC, et al. (2004) S-nitrosylation of parkin regulates ubiquitination and compromises parkin's protective function.

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  • These results implicate neuroinflammation-induced S-nitrosylation / nitration of mitochondrial complex I in mitochondrial malfunction and subsequent degeneration of the nigral dopamine neurons.

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  • Furthermore, defect in the mitochondrial respiratory chain, and extensive S-nitrosylation / nitration of mitochondrial complex I were detected prior to the dopaminergic neuronal loss.

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  • L-NIL treatment appears to prevent the LPS-induced increase of S-nitrosylation (C, D).

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  • Here, we showed that neuroinflammation is able to mediate mitochondrial impairment by S-nitrosylation / nitration of mitochondrial proteins.

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