Definitions
from Wiktionary, Creative Commons Attribution/Share-Alike License.
- adjective Not
activated
Etymologies
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Examples
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Through a lasting N-methyl-D-aspartate receptor and protein synthesis-dependent increase in protrusion growth and turnover, induction of plasticity promotes a pruning and replacement of nonactivated spines by new ones together with a selective stabilization of activated synapses.
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Figure 7C, we analyzed the proportion of activated versus nonactivated spines that had a new protrusion formed within a distance of 1.5 μm in the next 48 h (defined as hot spot).
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We then assessed the stability of activated and nonactivated spines for the next 3 d.
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(D) Differential long-term stability of activated (filled circles) and nonactivated spines
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To avoid biases, we then also verified that the size distribution of the spine heads did not differ between spines classified as activated and nonactivated
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As indicated, almost half of activated spines had a new spine growing close by, something that did not occur with nonactivated ones.
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Note, in addition, that the head width of nonactivated spines tended to become smaller after TBS and that the size of spine heads, when analyzed individually, showed regular fluctuations over consecutive days for both activated and nonactivated spines.
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(A) Illustration of a dendritic segment with line scan analyses made on an activated (1) and a nonactivated (0) spine.
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The net effect of LTP over several days was therefore to promote the replacement of nonactivated spines by new ones.
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In all experiments carried out, we verified that spines activated by stimulation were always surrounded by other silent, nonactivated spines in order to exclude global activation effects.
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