Definitions

from Wiktionary, Creative Commons Attribution/Share-Alike License

  • n. Without the state or quality of additivity.

Etymologies

from Wiktionary, Creative Commons Attribution/Share-Alike License

non- +‎ additivity

Examples

  • The establishment of such a link is sorely needed if we aim for a better understanding of the biological mechanisms underlying intra - and inter-locus additivity and nonadditivity.

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  • Here we show that by considering the additivity and nonadditivity features of each genotype explicitly, regulatory biology can be linked to the basic concepts of single locus genetic theory in a straightforward way.

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  • Since homoallelic or heteroallelic nonadditivity is a prerequisite for genetic dominance

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  • Our analysis suggests that any cis-acting eQTL showing genetic dominance points towards a possible feedback regulation or some other mechanism causing the nonadditivity.

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  • In these cases we predict that one will observe heteroallelic nonadditivity, but no homoallelic nonadditivity.

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  • This implies that it per definition cannot relate the nonadditivity between alleles in each genotype to the dominance value for RNA and protein phenotypes

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  • (eqn. (3)), another prediction is that homozygous loci showing homoallelic nonadditivity are hotspots for the creation of genetic dominant eQTLs in the genome.

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