from Wiktionary, Creative Commons Attribution/Share-Alike License.
- noun An
isomerof leucine, not found in natural proteins, used in experimental studies of protein structure and function.
from Wiktionary, Creative Commons Attribution/Share-Alike License
Amino acids are represented by the single-letter code (n is for norleucine).
The norleucine variant resulted in an alpha-helix rich protein that lacks the in vitro aggregation protein of the parent protein.
To prove these findings conclusively the scientists used an elegant trick: The methionine molecules were replaced with isosteric, chemically stable, non-oxidizable analogs, i.e. with the more hydrophobic norleucine (simulates non-oxidized methionine) and the highly hydrophilic methoxinine (simulates oxidized methionine).