from Wiktionary, Creative Commons Attribution/Share-Alike License.

  • noun An isomer of leucine, not found in natural proteins, used in experimental studies of protein structure and function.


from Wiktionary, Creative Commons Attribution/Share-Alike License

nor- +‎ leucine


  • Amino acids are represented by the single-letter code (n is for norleucine).

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  • The norleucine variant resulted in an alpha-helix rich protein that lacks the in vitro aggregation protein of the parent protein.


  • To prove these findings conclusively the scientists used an elegant trick: The methionine molecules were replaced with isosteric, chemically stable, non-oxidizable analogs, i.e. with the more hydrophobic norleucine (simulates non-oxidized methionine) and the highly hydrophilic methoxinine (simulates oxidized methionine).



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