Definitions

from Wiktionary, Creative Commons Attribution/Share-Alike License

  • n. The condition of having a normal level of oxygen.

Etymologies

from Wiktionary, Creative Commons Attribution/Share-Alike License

From normo- +‎ -oxia.

Examples

  • Cells in osteogenic differentiation medium at 5% and 20% oxygen exhibit an initial decrease in the redox ratio on day 4, followed by a consistent increase, with the mean values achieving statistically similar values to those of day 0, by day 8 (in the case of normoxia) or day 12 (in the case of hypoxia).

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  • COL 1a1 expression on day 8 was significantly higher under hypoxic conditions than it was in normoxia while on day 16 expression in the normoxic group was significantly higher than that at 5% oxygen.

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  • Day 4 represents the only time point at which hMSCs from the hypoxia propagation group (HP) have greater lipofuscin levels than those maintained in normoxia.

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  • To evaluate whether down-regulation of bcl-2 shows opposite effect of bcl-2 overexpression in terms of HIF-1α protein expression, we silenced the endogenous expression of bcl-2 gene transfecting M14 cells with siRNA-targeting bcl-2 mRNA (si-bcl-2) and then exposing them to normoxia or hypoxia for 24 h.

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  • Benizri E, Ginouves A, Volmat V, Roux D, et al. (2003) HIF prolyl-hydroxylase 2 is the key oxygen sensor setting low steady-state levels of HIF-1alpha in normoxia.

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  • (Bcl2/5) clones exposed to hypoxia or to normoxia for 24 h.

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  • Although under normoxia this HIF-1α stabilization is not sufficient to affect the steady state levels of the protein, it becomes rate limiting during hypoxia or, in general, in conditions strictly dependent on oxygen level.

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  • (B) Confocal laser scanning microscopy of immunofluorescence staining performed on Bcl2/5 stably overexpressing clone exposed to hypoxia or to normoxia for 24 h.

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  • (A) Western blot analysis of HIF-1α and bcl-2 protein expression in total extracts of M14 cells transfected with siRNA targeting bcl-2 mRNA (si-bcl-2) or with a control scrambled si-RNA (si-contr) and then exposed to normoxia or hypoxia for 24 h.

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  • (A) Western blot analysis of HSP90α and HSP90β protein expression in M14 control (puro) and bcl-2 stably overexpressing (Bcl2/5, Bcl2/37) clones exposed to hypoxia or to normoxia for 24

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