Definitions
from Wiktionary, Creative Commons Attribution/Share-Alike License.
- noun A
human monoclonal antibody under investigation for the treatment ofchronic lymphocytic leukemia and other diseases.
Etymologies
from Wiktionary, Creative Commons Attribution/Share-Alike License
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Examples
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Genmab, which is developing the drug with GlaxoSmithKline PLC, said it aims to submit the drug, called ofatumumab, for U.S. and European regulatory approval by the end of this year.
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"We are committed to the further development of ofatumumab in [non-Hodgkin's lymphoma]," said Genmab Chief Executive Lisa Drakeman.
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Genmab said it and Glaxo will continue to review the results of the non-Hodgkin's lymphoma study and discuss the development strategy for Arzerra in the treatment of the condition, which is also known as ofatumumab.
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About 44% of patients in the other group responded well to ofatumumab.
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After 24 weeks, 51% of patients in the group not responding to both older medicines experienced a strong response to ofatumumab, Genmab said.
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All of the patients were given eight weekly infusions of ofatumumab and then four monthly infusions.
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Glaxo is hoping that ofatumumab will boost its presence in the oncology business, which is growing at a faster rate than other disease areas.
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We are also evaluating the safety of PCI-32765 in combination with ofatumumab in a Phase IB/II study of patients with relapsed/refractory CLL/SLL.
unknown title 2011
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- In July, we announced positive interim data in the ofatumumab Phase II safety and pharmacokinetics study in patients with relapsing-remitting multiple sclerosis (RRMS).
News 2010
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Genmab is changing its 2010 financial guidance primarily as a result of the amendment of the ofatumumab co-development and commercialization agreement with GSK.
News 2010
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