from The American Heritage® Dictionary of the English Language, 5th Edition.
- adjective Tending to cause or give rise to tumors.
from Wiktionary, Creative Commons Attribution/Share-Alike License.
- adjective tending to cause the formation of
- adjective related to the formation of tumors
from The American Heritage® Dictionary of the English Language, 4th Edition
from Wiktionary, Creative Commons Attribution/Share-Alike License
However, these discoveries were soon forgotten and only after a long eclipse was interest in oncogenic viruses revived in the fifties.
Proteins that when expressed out of context cause a cell to become cancerous are known as oncogenic proteins.
Apart from monoclonal antibodies, small molecule therapeutics such as oncogenic protein kinase inhibitors are attracting a vast amount of investigational attention.
In 1969 – 70, the isolation of an RNA-polymerase associated with the viral particles of the vesicular stomatitis virus led to the idea that perhaps a key enzyme was also associated with the oncogenic RNA viruses.
We showed that naked DNA alone carried all the oncogenic potential of the virus.
Working on a small oncogenic DNA virus, polyoma, I could show there, with I. Macpherson, a new property of transformed cells, that of growing in soft agar.
In order to perfect my knowledge of oncogenic viruses, I moved from Carshalton to Glasgow where a new Institute of Virology had been recently inaugurated, headed by a remarkable virologist, Michael Stocker, and where many high-ranking visitors, among them Renato Dulbecco, were spending sabbatical years.
Our genetic evidence from Drosophila and previous in vitro studies of mammalian Atonal homolog 1 (Atoh1, also called Math1 or Hath1) suggest an anti-oncogenic function for the Atonal group of proneural basic helix-loop-helix transcription factors.
A great mystery remained at that time: that of the replication of the oncogenic RNA viruses, now known as retroviruses.
Back to France at the Institut Curie, I extended this finding to a number of cancer cells, transformed or not by oncogenic RNA or DNA viruses.