optineurin

The present study was undertaken to illustrate the basic characteristics of optineurin.

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Turnover experiments showed that the endogenous optineurin was relatively short-lived, with a half-life of approximately 8 hours.

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The inducible optineurin-GFP-expressing cell lines are also anticipated to facilitate in-depth studies of optineurin.

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One of the candidate genes, optineurin, is linked principally to normal tension glaucoma, a subtype of POAG.

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Treatment of nocadazole resulted in dispersion of the optineurin foci.

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It was found that while phosphorylated, optineurin was neither N - nor O-glycosylated, and was by itself not a membrane protein.

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The present study provides new information regarding basic characteristics of optineurin that are important for future efforts in defining precisely how optineurin functions normally and how mutations may result in pathology.

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The endogenous optineurin exhibited a diffuse, cytoplasmic distribution, but a population of the protein was associated with the Golgi apparatus.

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When overexpressed, optineurin-green fluorescence protein (GFP) fusion protein formed punctate structures termed "foci" in the perinuclear region.

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Furthermore, the demonstrations that optineurin is an aggregation-prone protein and that the foci formation is microtubule-dependent bear similarities to features documented in neurodegenerative diseases, supporting a neurodegenerative paradigm for glaucoma.

Elites TV PLoS ONE 2010