from Wiktionary, Creative Commons Attribution/Share-Alike License

  • adj. That stimulates the appetite.

from The Century Dictionary and Cyclopedia

  • Stimulating the appetite. An orexigenic and stomachic action which is not to be lightly esteemed.


Sorry, no etymologies found.


  • NPY and AgRP stimulate feeding behavior therefore called orexigenic peptides

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  • Research in adult animals by Leibowitz and others has shown that circulating triglycerides stimulate brain chemicals known as orexigenic peptides, which in turn spur the animals to eat more.

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  • Accordingly, the orexigenic effect of ghrelin is absent in NPY/AgRP double knockout mice, despite unaltered growth and feeding

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  • Activation of cannabinoid type-1 receptors (CB1) is universally recognized as a powerful endogenous orexigenic signal, but the detailed underlying neuronal mechanisms are not fully understood.

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  • It is not clear by what mechanisms a reduction in immunoreactivity for the orexigenic peptide AgRP in the PVH of ob/ob, DIO and OffOb rodents might be associated with their hyperphagia.

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  • Alternatively, it possible that AgRP-immunoreactivity in the PVH is depleted due to increased local release of this peptide, albeit from a reduced number of processes; if the net effect were orexigenic, the apparent paradox would be resolved.

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  • Neurons synthesising agouti-related peptide (AgRP) are restricted to the ARC and contain the orexigenic neuropeptide Y consequently all AgRP-immunoreactivity detected in the PVH derives from neurones in the ARC.

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  • Leptin plays a key role in energy balance through inhibition of orexigenic systems and stimulation of anorexigenic systems in the ARC

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  • We have also assessed behavioural and cell-signalling responses to exogenous leptin and the density of immunoreactivity for orexigenic and anorexigenic peptides in the hypothalamic paraventricular nucleus (PVH) prior to the onset of hyperphagia.

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  • Therefore, in this study the levels of ghrelin and orexin A - peripheral and central peptide from the orexigenic gut-brain axis were determined.

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