Definitions
from Wiktionary, Creative Commons Attribution/Share-Alike License.
- adjective Of or pertaining to
orotic acid or its derivatives
Etymologies
from Wiktionary, Creative Commons Attribution/Share-Alike License
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Examples
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Then a urine test, taken after Harrison emerged from his coma, showed abnormally high levels of certain chemicals - in particular, one called orotic acid.
Telegraph.co.uk - Telegraph online, Daily Telegraph and Sunday Telegraph Cherrill Hicks 2012
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Then a urine test, taken after Harrison emerged from his coma, showed abnormally high levels of certain chemicals - in particular, one called orotic acid.
Telegraph.co.uk - Telegraph online, Daily Telegraph and Sunday Telegraph Cherrill Hicks 2012
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Although orotic acid isn't officially considered a vitamin these days, over 40 years ago it was found to have growth-promoting, vitamin-like properties when added to the diets of laboratory animals.
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But notice that orotic acid also increases in potency in going from free OA to its magnesium complex, an enhancement consistent with the idea that magnesium orotate gets preferentially directed toward uridine synthesis by OPRTase.
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There are other vital roles for orotic acid and uridine in the body-for example, OA gets taken up by red blood cells where it is rapidly converted to UDP-glucose by way of OPRTase and other enzymes.
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Orotates are the mineral salts of orotic acid, a natural substance found in our bodies and also in various foods including dairy products.
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The authors suggested that lithium acts at the membrane level and that the effects on RNA metabolism are due to changes in the transport of radiolabeled orotic acid-an explanation entirely consistent with Nieper's idea that lithium combines with OA to yield a transportable complex.
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In other words, a synergy exists between magnesium and orotic acid such that the complex they form-magnesium orotate-is more potent than either one alone.
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Model rats were established by administration with 1% orotic acid (OA).
BioMed Central - Latest articles Xiao-Qian Hu 2010
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Thus a mechanism exists for explaining why magnesium orotate works even better than orotic acid for heart conditions.
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