Definitions

from Wiktionary, Creative Commons Attribution/Share-Alike License

  • n. Plural form of ortholog.

Etymologies

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Examples

  • The following protein pairs could be unambiguously identified as orthologs on the basis of common domain architecture and high sequence identity: (A) C34F11. 9a / DVL2, (B)

    PLoS Biology: New Articles

  • For comparison, we also gathered the closest non-orthologs, meaning sequences close in sequence space, yet falling just outside the ortholog cluster.

    BioMed Central - Latest articles

  • We might still be able to distinguish between orthologs and paralogs, as a matter of logical principle but, in practice, this will often be impossible.

    A Disclaimer for Behe?

  • The conservation was defined based on an alignment window of +/- 10AAs of S. cerevisiae proteins against orthologs in C. albicans, S. pombe, D. melanogaster and H. sapiens.

    Translationally optimal codons do not appear to significantly associate with phosphorylation sites

  • But it * is* mentioned that orthologs and paralogs of these genes gave rise in later metazoan evolution to other components of other types of nerve cell junctions.

    Another predictable argument against front-loading

  • From here there are a set of loops and conditional statements that you can include to get the list of orthologs:

    Archive 2007-03-01

  • To illustrate how easy it is to use it I have built a Kapow robot to get, for any human geneID, a list of orthologs with species and IDs.

    Archive 2007-03-01

  • The evolutionary analysis was aided by sequencing the entire coding region of CARD15 in three primates chimp, gibbon, and tamarin and aligning the human sequence with these and orthologs from other species.

    Another One Bites the Dust - The Panda's Thumb

  • For example, whereas in urochordates the ancestral Hox cluster has fragmented, the individual genes show high levels of sequence identity and similar A/P-restricted patterns of expression to their orthologs in other bilaterians.

    Jellyfish lack true Hox genes! - The Panda's Thumb

  • To determine the impact of divergence on the changes in the regulatory networks one can also look at how conserved are the regulatory regions of the same proteins in different species orthologs.

    Archive 2006-09-01

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